Here’s a startling fact: as cancer treatments evolve, older adults are increasingly relying on complex therapies like Antibody-Drug Conjugates (ADCs), yet many healthcare professionals remain unsure how to manage them effectively. But here’s where it gets controversial: Are we truly prepared to address the unique challenges these patients face? Fresh insights from the SIOG 2025 Annual Conference (https://siog.org/events/siog-events/siog-2025-annual-conference/) shed light on this critical issue. The session, “Nursing Essentials in Antibody-Drug Conjugates (ADCs) for Older Adults with Cancer,” brought together oncology nurses, nurse practitioners, clinical specialists, and allied health professionals to tackle the complexities of ADC use in this vulnerable population. With ADCs now at the forefront of modern oncology, the discussion emphasized the indispensable role nurses play in ensuring safe administration, early toxicity detection, and compassionate communication—all tailored to the unique needs of older adults.
Cindy Kenis (Leuven, Belgium) kicked off the session by framing the learning objectives and underscoring why ADCs matter in geriatric oncology. She pointed out that as these therapies become more widespread, nursing teams must not only grasp the science behind them but also understand how age-related vulnerabilities—like frailty and multimorbidity—shape clinical decisions and care delivery. And this is the part most people miss: Older adults aren’t just ‘older versions’ of younger patients; they’re a distinct clinical group requiring personalized nursing approaches.
In the first module, Capucine Baldini (Villejuif, France) demystified ADCs, explaining how their unique structure—combining a monoclonal antibody, cytotoxic payload, and linker—enables precise drug delivery to tumors while minimizing systemic side effects. She reviewed commonly used ADCs in older adults and explored how factors like polypharmacy and frailty can alter treatment outcomes. Her message was clear: individualized care is non-negotiable for this population.
The second module, led by Ana Carolina Grisotto (São Paulo, Brazil), dove into the toxicities associated with ADCs and the frontline role nurses play in managing them. From hematologic suppression to peripheral neuropathy, she stressed that early recognition is key to safe care. Grisotto also highlighted practical strategies for monitoring, symptom management, and involving caregivers, reminding attendees that nursing vigilance can make or break treatment success.
After a brief intermission, a case-based workshop led by Nicolò Matteo Luca Battisti (Sutton, United Kingdom), Bonnie Leung (Vancouver, Canada), and Allison Magnuson (Rochester, United States) bridged theory with practice. Participants analyzed a real-world scenario, applying assessment techniques, monitoring strategies, and communication skills to an older patient receiving ADCs. The exercise showcased how multidisciplinary collaboration and geriatric principles intersect in daily care, while facilitators flagged critical ‘red flags’ requiring immediate action.
The final module, presented by Vanya Slavova-Boneva (Sutton, United Kingdom) and Bonnie Leung, tackled the operational side of ADC delivery. From handling protocols to personal protective equipment, they emphasized safety for both patients and healthcare staff. The session wrapped up with a recap of key takeaways, Q&A, and certification details.
Throughout the modules, one message resonated: as ADCs become mainstream in cancer care, nurses are the linchpin for their successful use in older adults. This role demands a blend of scientific expertise, geriatric insight, and empathetic communication. The SIOG 2025 session provided a practical roadmap for nurses navigating this evolving landscape.
Controversial question to ponder: Are we doing enough to train healthcare professionals in geriatric-specific oncology care, or are we leaving older adults at risk? Share your thoughts in the comments below. For more details, click here (https://siog2025.abstractserver.com/program/#/details/sessions/21).
